Postdoctoral Researcher – Establishing 3D microtissue models for studying urogenital bacterial infections (100%)

The Biozentrum of the University of Basel is one of the leading Life Sciences Institutes in the world. It accommodates 30 research groups and 500 employees investigating how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birthplace of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

A postdoctoral position is available in the group of Prof. Christoph Dehio (www.biozentrum.unibas.ch/dehio).

This position is supported by the NCCR AntiResist: New Approaches to Combat Antibiotic-Resistant bacteria. NCCR AntiResist (https://nccr-antiresist.ch/) is a Swiss-wide interdisciplinary center for antibiotic research with strong collaborations between biologists, clinicians, engineers, computational scientists and chemists. The goals of NCCR AntiResist are to elucidate pathogen physiology in infected patients, followed by the development of in-vitro models that faithfully mimic conditions in the patient, and to use these laboratory models to discover innovative strategies to combat antibiotic-resistant bacteria. In this position, the candidate will focus on establishing 3D microtissue models for studying urogenital bacterial infections. This research project is embedded within the work package Escherichia coli of NCCR AntiResist (www.nccr-antiresist.ch/en/research/work-packages-overview/escherichia-coli)

Your responsibilities are

  • to develop microtissue models of the human urogenital tract (e.g., bladder and kidney)
  • to utilize these microtissue models for studying infection with uropathogenic bacteria, and to visualize and quantify changes in bacterial physiology at single-cell level upon treatment with antibiotics
  • to analyze data using appropriate statistical methods
  • to present data in a professional format suitable for publication
  • to act as an experienced resource, and demonstrate clear and professional verbal and written communication skills

Your profile

You obtained a PhD in one of the following disciplines: microbiology, cellular/molecular biology, biophysics, or image analysis. You have a profound expertise in 3D microtissue or other microphysiological models of diseases, host-pathogen interaction or the development and use of single-cell analysis methods based on microfluidics, live-cell imaging and image analysis. Experience with advanced imaging techniques, single-cell reporters, machine learning-based image analysis or microfluidics would be of great advantage. Good teamworking skills are indispensable.

We offer

A highly motivated team as part of a multidisciplinary group at the Biozentrum including microbiologists and cell biologists with an expertise in virulence and persistence of Escherichia coli and other human pathogens. Moreover, the Biozentrum offers excellent internal support from various core facilities with expert staff as well as a very strong multidisciplinary collaborative environment within the frame of the NCCR AntiResist.

The position is available immediately and the prospective funding period is for at least three years.

Basel is an international city with people from 150 nations. Located on the border between Switzerland, Germany and France, it is Europe’s most important Life Science hub. Basel provides a high standard of living and a rich and varied cultural atmosphere. NCCR AntiResist embraces diversity and equal opportunity. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills. The more inclusive we are, the better our work will be.

Application / Contact

Please apply online and upload the following three separate PDF documents: 1) Your CV with contacts for three references 2) Motivation letter explaining why you are a good candidate for this job offer 3) List of all your publications (including pre-prints). For up to three publications most relevant to this job offer describe shortly (up to 200 words) your role as well as why the publication is relevant (for example: what techniques you learned, what experience you gained, etc.).

Incomplete applications will be disregarded. Reviewing of applications will begin on April 1, 2021 and continue until the position is filled. For general inquiries, please send an e-mail to dehiostelle@unibas.ch.


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