The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 30 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birthplace of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.
Skilled and motivated individuals are encouraged to apply for a 4-year PhD Fellowship in the research group of Roderick Lim at the Biozentrum, University of Basel, Switzerland.
The Lim Lab is interested in nuclear pore complex (NPC) function and the regulation of nucleocytoplasmic transport (NCT). Importantly, malfunctioning NPCs and defective NCT are linked to aging as well as pathologies ranging from cancer to neurodegenerative disorders and viral pathogenesis.
In this project, we want to study novel function(s) of nuclear transport receptors, their regulation at NPCs and implications in human disease. Methods will comprise, amongst others, CRISPR-based genome editing, state-of-the art confocal imaging (including FRET, FRAP, and super-resolution techniques) and atomic force microscopy (AFM).
Besides basic research, PhD candidates will also have to contribute to undergraduate level teaching.
Interested candidates should have a background in molecular cell biology, biophysics or related disciplines. Experience in optical/fluorescence imaging or AFM, including high-speed AFM is a plus. The successful candidate is expected to be highly interactive and capable of independent research in a team environment. A solid command of oral and written English is essential.
We are a multi-national, interdisciplinary lab that combines biophysical, molecular and cellular approaches to investigate intriguing biological problems. The successful applicant will benefit from a highly stimulating, collaborative research environment as well as state-of-the-art infrastructure and facilities at the new Biozentrum research tower.
Basel is an international city with people from 150 nations. Located on the border where three countries meet - Switzerland-Germany-France - it is Europe’s most important life sciences hub. Basel provides a high standard of living and a rich and varied cultural atmosphere.
The application should include a cover letter, CV, diplomas and 3 reference letters. Reviewing of applications will start immediately and continue until the position is filled. Please note that only online applications will be accepted.
For further information, please contact stephanie.gehlen@unibas.chThe Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 30 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birthplace of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.
A three-year postdoctoral position is available at the Biozentrum (Basel, Switzerland) in the context of a SNF project led by Dr. Thomas Julou. The position is embedded in the group of Prof. Erik van Nimwegen and the starting date is flexible, between September 2021 and January 2022. The postdoctoral fellow will be supervised by T. Julou and E. van Nimwegen.
The van Nimwegen Lab at Basel University’s Biozentrum is an international and multidisciplinary team with extensive expertise in the field of transcription regulation, cell-to-cell variability, genome evolution, and probabilistic data analysis techniques. A special feature of our group is that it includes both experimental and theoretical researchers which work together to combine cutting edge statistical and computational tools with quantitative experiments. A list of our group's publications can be found on Google Scholar
The topic of this project concerns Escherichia coli during stationary phase, as a case study of non-growing bacteria. Although bacteria in the wild likely spend the majority of their time in non-growing states, relatively little is known about cell physiology and gene expression in such states, especially at the single-cell level. Our lab uses novel quantitative approaches, such as the one we recently developed to quantitatively track growth and gene expression with single-cell resolution in bacteria exposed to controlled environmental changes [1, 2]. We are interested in both physiological and evolutionary aspects of stationary phase: What are the different physiological states that can be attained during stationary phase? What is the extent and dynamics of cell heterogeneity during stationary, and how does this heterogeneity affect survival, stress-resistance, and the ability of cells to regrow when exposed to new nutrients? Are there evolutionary trade-off(s) between growth-related traits and starvation-related traits? To answer such questions, the candidate is expected to combine experimental techniques from molecular biology, genetics, video-microscopy, microfluidics and microfabrication, with cutting-edge data analysis and modelling techniques, which may be undertaken in collaboration with theoretical researchers in the lab. The project will be tailored to the interests and skills of the successful candidate, and will take advantage of results already obtained by a PhD student in our group.
Applicants should have completed a PhD in a relevant field such as biophysics, quantitative biology, microbiology, or evolution. Previous experience with microscopy and microfluidics will be valued. Experience with quantitative analysis and programming skills are a plus as well.
The application should include a CV and motivation statement as well as the contact details of at least two references. Reviewing of applications will start immediately and continue until the position is filled. Please note that only online applications will be accepted.
For specific questions, feel free to contact Thomas Julou, e-mail: thomas.julou@unibas.chThe Biozentrum of the University of Basel in Switzerland invites applications for a tenure-track assistant professorship in Tissue Assembly, Physiology, and Engineering. This position will be supported by the Biozentrum (https://www.biozentrum.unibas.ch/) and the National Center of Competence in Research (NCCR) "AntiResist: New Approaches to Combat Antibiotic-Resistant Bacteria" (2020-2032; https://nccr-antiresist.ch/). The Biozentrum is one of the leading Life Sciences Institutes in the world. It investigates how molecules and cells create life, spanning the scale from atom to organism. The NCCR "AntiResist", whose home institution is the University of Basel, is a Swiss-wide interdisciplinary center for infection biology and antibiotic research.
We seek an imaginative and creative early career scientist who will bring his/her expertise in tissue assembly, physiology, and engineering to important problems in biology and medicine.
The new professor will complement and enhance the research portfolio of the Biozentrum and the NCCR "AntiResist", as well as the broader Basel Life Sciences Community, and will contribute to teaching at the undergraduate and graduate level.
Applicants should have an outstanding track record of research accomplishments. We are interested in candidates with expertise in areas such as tissue development, organization, physiology, or engineering, stem cell biology, organogenesis or organoids. The candidate should have an interest in developing tissue models for human infections, and collaborate with basic and applied researchers to explore fundamental questions in biology and medicine.
We offer a very generous research endowment, including support for students, postdocs, technicians and consumables, and state-of-the-art core facilities. The Biozentrum accommodates 30 research groups and 250 postdoctoral fellows and graduate students from more than 50 countries researching in fields ranging from structural, computational, cellular and developmental biology to microbiology and neuroscience. The NCCR "AntiResist" comprises a network of academic institutions and collaborating companies in Basel, Zurich and Lausanne consisting of 29 research groups spanning five major disciplines: clinical medicine, engineering, biology, chemistry, and computational biology. The research environment of the Biozentrum and the NCCR "AntiResist" is a stimulating and vibrant environment offering unique opportunities for a wide range of collaborations across disciplines and with other departments. Basel is the home of a vibrant international life sciences community and provides a high standard of living and a superb cultural and cosmopolitan atmosphere.
Applications (including CV, a list of publications, a letter of motivation, and a two-page summary of past, present and future research) should be addressed to Prof. Dr. Marcel Mayor, Dean of the Faculty of Science and submitted online as one single PDF via this platform. During online submission, applicants are asked to request three referees to submit confidential letters of reference. Requests for further information may be addressed to Alex Schier (alex.schier@unibas.ch) regarding the Biozentrum of University of Basel and Christoph Dehio (christoph.dehio@unibas.ch) regarding NCCR "AntiResist". If your question is about the online application process, please contact the Office of the Dean (dekanat-philnat@unibas.ch).
The deadline for receipt of applications is September 20, 2021. The University of Basel is an equal opportunity and family-friendly employer committed to excellence through diversity. We are keenly interested in diversifying our faculty and encourage applications from female candidates.
The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 30 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birthplace of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.
A PhD position funded by the Swiss National Science Foundation is available from September 2021 onwards in the group of Prof Jan Pieter Abrahams at the Biozentrum of the University of Basel.
Cryo-electron microscopy can reveal the atomic structures of biological molecules by focusing the electrons that are scattered by the sample into an image. These electron images have low contrast and are very noisy, because electron beam damages the sample.
The Abrahams group has generated strong evidence that the signal-to-noise ratio of the electron image can be boosted significantly by measuring the scattered electrons directly. This resulted in the development of protein nano-crystallography (micro-ED) and we are extending the method to include non-crystalline samples and single molecule electron diffraction (simED). Novel, dedicated hardware will allow us to develop methods for automatically generating vast amounts of electron diffraction data short periods of time. We aim to develop novel tools based on Artificial Intelligence and Big Data technologies for interpreting these data. An important biological focus of our group is on molecular machines for protein degradation. (I. Mohammed, K. A. Schmitz, N. Schenck, T. Maier, J. P. Abrahams, Catalytic cycling of human mitochondrial Lon protease. Sci. Adv. 7, eabf0156 (2021). Part of the work will be performed at, and will be supported by the Paul Scherrer Institute (https://www.psi.ch/en).Phasing protein simED data. Your project is part of an overall project of our group to establish novel technologies and methods for biomolecular structure determination. This project has several sub-goals: (i) identifying diffraction patterns that likely correspond with single molecules, (ii) low-resolution phasing, for instance by molecular replacement methods or (in collaboration with another project) imaging and/or ptychography, (iii) phase extension through model building and refinement. This project is anticipated to lean heavily on novel concepts for pattern recognition, using Artifical Intelligence / neural network analysis of big data sets.
We offer an exciting and stimulating work environment with scientific collaborations within the institute and worldwide.
Basel is an international city with people from 150 nations. Located on the border where three countries meet - Switzerland-Germany- France -, it is Europe’s most important life sciences hub. Basel provides a high standard of living and a rich and varied cultural atmosphere.Please apply online with a cover letter, CV, reference letters, diplomas and contact information of two referees: Please note that only online applications will be accepted:
For any informal enquiries, please contact: jp.abrahams@unibas.ch