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Research-assistant position: "Development of Bioassays for Measuring Nanoparticle - Protein interactions" (100%)

The Biozentrum of the University of Basel, Switzerland is one of the leading institutes worldwide for molecular and biomedical basic research and teaching. It is home to more than 30 research groups with scientists from over 40 countries. Research at the Biozentrum focuses on the areas of Cell Growth & Development, Infection Biology, Neurobiology, Structural Biology & Biophysics and Computational & Systems Biology. With its more than 550 employees, the Biozentrum is the largest department at the University of Basel’s Faculty of Science.

We are offering a 1-year research-assistant position on the topic of “Development of Bioassays for Measuring Nanoparticle - protein interactions” in the research group of Prof. Torsten Schwede. This project is embedded within the Nanoscreen Consortium, an excellent international collaborative network of industrial and academic partners in engineered nanomaterials design, production, characterization, in vitro testing and measurement-science.

Your responsibilities

The goal of this specific research project is the investigation of binding mechanisms of proteins to nanoparticles of different materials and sizes. You will produce recombinant proteins and develop analytical tools to study protein-nanoparticle interactions systematically. Some of your analytical work will be carried out in specialized partner-laboratories around Switzerland. The aim of the study is to correlate the nanoparticle interaction patterns in vitro with bio-responses observed within the consortium. This work is expected to contribute to predictive nanotoxicology, with numerous potential applications in the design of novel nanomaterials.

Your profile

  • Excellent practical knowledge in protein biochemistry, bioassays and analytics
  • Solid theoretical background and technical experience in biochemistry, chemistry, nanoscience, material science or similar
  • Interdisciplinary mindset, hands-on and high motivation for collaborative work

Applicants should have very strong practical research experience, particularly in protein biochemistry and bio-analytics, including developing ELISA or similar assays. Attention to detail, a systematic & self-organized working style, motivation to take on new challenges, good team-working and communication skills are essential for this collaborative project.

The workplace

The Schwede group is renowned for SWISS-MODEL (swissmodel.expasy.org), a widely used automated protein structure homology-modelling server. The molecular modelling activities of the group are complemented with a well-equipped experimental laboratory at the Biozentrum, where most of the work will be performed.

Application Instructions

The position is available immediately and is limited to one year. The University of Basel, Switzerland is an equal opportunity employer and encourages applications from both female and male candidates.

Please submit your application online through the Biozentrum website including a CV, a letter of motivation highlighting your personal interests and contributions to the field of protein biochemistry and bioassays, as well as contact information of referees. Incoming applications will be evaluated continuously until the position is filled.

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Molecular Biology and Biochemistry Technician (100%)

The Biozentrum of the University of Basel is one of the leading institutes worldwide for molecular and biomedical basic research and teaching. It is home to more than 30 research groups with scientists from over 40 countries. Research at the Biozentrum focuses on the areas of Cell Growth & Development, Infection Biology, Neurobiology, Structural Biology & Biophysics and Computational & Systems Biology. With its more than 500 employees, the Biozentrum is the largest department at the University of Basel’s Faculty of Science.

The Mango group will be moving from Harvard University to the Biozentrum in Basel, Switzerland in 2018. We are looking to recruit a highly motivated technician to join the group starting upon mutual agreement. The first few months of this position will be spent at Harvard University in Cambridge, MA and will subsequently move to Basel. The position is funded for two years, with the possibility of renewal.

Your responsibilities are

We seek a skilled technician to use modern molecular approaches to study chromatin biology during development. This person will assist and train members of the lab in chromatin methods such as ChIP, FAIRE, proteomics, and he or she will also have a scientific project of their own.

Your profile

Applicants should have a degree as a laboratory technician or a degree in molecular biology or related topics. Previous experience in biochemistry, chromatin analysis (FAIRE, ChIP, HiC, IP) and excellent technical skills are highly desirable. The role requires flexibility, good organizational and communication abilities, and a talent to multi-task. Enthusiasm and motivation for biological research are critical, and enjoyment in teaching others is a must. The primary language of the laboratory and the Biozentrum is English.

We offer

This position offers an exciting opportunity for a highly motivated individual to organize a lab and contribute to a vibrant research community.

Application

Please apply online including covering letter, CV, reference letters, diplomas and contact information of two referees by November 30, 2017 at the latest.

The position will start upon mutual agreement. For further information please contact Prof. Susan Mango, email: smango@mcb.harvard.edu

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Proteomics IT Specialist (100%)

The Biozentrum of the University of Basel is one of the leading institutes worldwide for molecular and biomedical basic research and teaching. It is home to more than 30 research groups with scientists from over 40 countries. Research at the Biozentrum focuses on the areas of Cell Growth & Development, Infection Biology, Neurobiology, Structural Biology & Biophysics and Computational & Systems Biology. With its more than 500 employees, the Biozentrum is the largest department at the University of Basel’s Faculty of Science. We are looking to recruit a self-motivated Proteomics IT Specialist to join our Proteomics Core Facility (PCF). The PCF provides state-of-the art proteomic techniques to support life science research at the Biozentrum. It is tightly integrated in an internationally leading scientific surrounding and in multiple interdisciplinary projects. The main focus of the group is the development and application of sensitive mass spectrometric workflows for system-wide and specific protein profiling.

Your responsibilities

The position’s responsibilities will be the support, maintenance and advancement of the IT infrastructure of the facility in collaboration with the local IT specialists. The PCF offers a wide range of workflows focusing on global (LFQ, TMT, SWATH) and, in particular, targeted (SRM/PRM) protein quantification using different commercial and in-house data-analysis pipelines. A major task will be the development of software and computational tools for the generation of targeted MS assays for DIA workflows and the analysis and interpretation of the quantitative mass spectrometric datasets. This includes the implementation of informatics solutions to manage, display and search proteomics datasets, the database-based management of results and the possibility for independent research projects.

Your profile

The successful candidate should have a degree in a life science or computational discipline. Prior experience with the analysis of proteomics data and excellent skills in at least one programming or scripting language (such as Perl, Java, R, Python and/or C/C++) are essential. Hands-on experience with LC-MS systems and experience in the statistical analysis of large biological datasets would be advantageous. Besides, the successful candidate should have a good understanding of Linux and Windows operation systems. In addition, the role requires good communication and organization skills, the ability to work well in a team, as you will work closely with research scientists, other bioinformaticians and members of the PCF, as well as advanced knowledge of English.

We offer

The position offers a challenging opportunity to join a growing and rapidly evolving bioanalytical field and to join a team of highly motivated scientists. The position is initially for 2 years, with the possibility of further extension after positive evaluation. Salary and benefits according to University of Basel standards.
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