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Currently open positions

PhD students – biophysics and cell biology

The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 30 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birth place of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

The research group of Prof. Stephan Grzesiek at the Biozentrum seeks to appoint a PhD student in biophysics with a focus on kinase regulation, to start immediately or as per arrangement.

The project

We are applying and developing modern NMR methods and other biophysical techniques to elucidate the functional mechanisms of disease-relevant proteins at an atomic level. For an overview of current research projects and publications, please visit https://www.biozentrum.unibas.ch/grzesiek.

The PhD project is aimed at deciphering the regulation mechanism of Abelson kinase (Abl), which is a drug target against chronic myelogeneous leukemia (CML). It is foreseen to describe Abl’s regulation, oncogenic disregulation, and reaction to cancer drugs by a combination of various biophysical techniques. As such it will also involve expression and in-cell observations in mammalian cell lines. The project will be carried in close collaboration with the group of Prof. Oliver Hantschel, Biochemisch-Pharmakologisches Centrum, University of Marburg (https://www.uni-marburg.de/de/fb20/bereiche/bpc/physiolchemie).

Your profile

We are looking for a highly motivated and talented PhD student to join our lab. Candidates must have a master degree in biochemistry, physical chemistry, physics or a related scientific discipline at the time of the PhD start. They should have experience in one or several of the following fields: molecular biology or cell biology with a background in protein structure, biomolecular fluorescence spectroscopy, or macromolecular NMR.

We offer

We offer a highly interactive, multidisciplinary, and international research group with expertise in many areas of biophysics. The technical equipment includes state-of-the art high-resolution NMR spectrometers, single-molecule FRET, as well as many other biophysical technologies and an advanced protein expression lab. Moreover, the Biozentrum provides excellent internal support from various core facilities with expert staff. The PhD training will include formal education within the Biozentrum’s graduate teaching program (https://www.biozentrum.unibas.ch/education/graduate-teaching-program/teaching-cycles/).

Basel is an international city with people from 150 nations. Located on the border where Switzerland, Germany, and France meet, Basel is home for a large number of institutions for biomedical research, with numerous possibilities for training, networking, and career development. Basel provides a high standard of living and a rich and varied cultural atmosphere.

Application / contact

Application deadline: 31 August 2022. The application should include a brief statement of your scientific interests, your research experience, and your particular interest in this open position. In addition, a CV and the contact information of two references is required.

For any informal enquiries, please contact Stephan Grzesiek (stephan.grzesiek@unibas.ch).
Apply now

Assistant/Associate Professor in Molecular, Cellular or Systems Biology

The Biozentrum of the University of Basel in Switzerland invites applications for a tenure track assistant professorship or a tenured associate professorship in molecular, cellular or systems biology. All candidates exploring fundamental questions in modern biology will be considered, ranging from the physics of life to the dynamics of multicellular systems.

Your position

The successful candidate will have an outstanding research record and strong communication skills, will complement and enhance the research portfolio of the Biozentrum as well as the broader Basel Life Sciences Community, and will contribute to teaching at the undergraduate and graduate level.

We offer

We offer a very generous research endowment and state-of-the art core facilities. The Biozentrum consists of 30 research groups and 250 postdoctoral fellows and graduate students from more than 50 countries researching in fields ranging from structural, computational, cellular and developmental biology to microbiology and neuroscience. Basel is the home of a vibrant international life sciences community and provides a high standard of living and a superb cultural and cosmopolitan atmosphere.

Application/Contact

Applications (including a short motivation letter, CV, a list of publications, and a two-page summary of your current and future research) should be addressed to Prof. Dr. Marcel Mayor, Dean of the Faculty of Science and submitted online as one single PDF. During online submission, applicants are asked to request three referees to submit confidential letters of reference. Requests for further information may be addressed to Prof. Dr. Alex Schier (alex.schier@unibas.ch). If your question is about the online application process, please contact the Office of the Dean (dekanat-philnat@unibas.ch).

The deadline for receipt of applications is September 15, 2022. The University of Basel is an equal opportunity and family-friendly employer committed to excellence through diversity.

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Postdoctoral position in neural circuit research

The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 30 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birth place of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

The laboratory of Peter Scheiffele is looking for a postdoctoral fellow.

The project

We are recruiting a highly motivated scientist to join our team working on in vivo imaging and identification of cellular and molecular mechanisms of cortical circuit development and function in mice. We are a cellular/molecular neuroscience lab and study the development of neuronal connectivity in health and disease states.

We are establishing innovative genetic marking and sensor approaches for advanced in vivo imaging and in vivo cell biology studies. Our projects bridge molecular work on cell type- and synapse-specific functions to imaging and behavior.

Your profile

The successful candidate should be highly motivated to contribute to our efforts on dissecting mechanisms of neural circuit and synapse formation. They are expected to take a leading role in 2-photon imaging experiments (data acquisition and analysis), aligned with molecular studies on synaptogenesis and plasticity. Experience with 2-photon equipment, data acquisition, and programming experience are required. In addition, we expect excellent communication and organizational skills, and the ability to work as a team member.

We offer

Work in the Scheiffele Lab is supported by state-of-the-art facilities in optical and electron microscopic imaging, computational biology, genomics, and research IT, as well as excellent mechanic and electronic workshops. The Biozentrum is based in the vibrant city of Basel, Switzerland, which offers an exceptional scientific and cultural environment.

Application / contact

Please submit your application, including your CV, motivation letter and email addresses for 2 referees.

Applications will be reviewed as they are received.

For further information please contact Peter Scheiffele (peter.scheiffele@unibas.ch).
Apply now

Postdoctoral Researcher in the laboratory of Prof. Marek Basler at the Biozentrum of University of Basel (full time position)

Understanding dynamics of the bacterial Type VI secretion system assembly

The Biozentrum of the University of Basel is one of the leading Life Sciences Institutes in the world. It accommodates 30 research groups and 500 employees investigating how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birthplace of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

A postdoc position is available in the group of Prof. Marek Basler at the Biozentrum, University of Basel.

The Type VI secretion system (T6SS) is a unique protein-translocating bacterial nanomachine that is fascinating from several points of view: (i) T6SS clusters are present in numerous pathogenic bacteria, (ii) T6SS can deliver effectors into both bacterial and eukaryotic targets, (iii) components of T6SS are evolutionarily related to phage tails, (iv) dynamics of T6SS can be studied using fluorescence microscopy in live cells allowing unprecedented insights into function of this complex nanomachine.

Recently, we have identified several different mechanisms regulating T6SS assembly with high spatial and temporal precision (i.e., aiming of T6SS). In this project we will uncover fundamental principles of “aiming” of T6SS assembly in various bacteria. We will primarily focus on the following biological questions: How is T6SS assembly initiated, regulated and localized? What are the sequential steps of T6SS assembly? How these steps vary between species? How does aiming of T6SS contribute to its activity?

Your responsibilities are

  • Work with various bacterial strains and generate their variants to unravel novel phenotypes related to T6SS activity.
  • Develop novel approaches to image localization and dynamics of T6SS components in live bacterial cells.
  • Work with state-of-the-art wide-field, confocal, and super resolution microscopes.
  • Analyze, interpret and present wide-range of data and results.
  • Collaborate with researchers with various backgrounds to advance projects in the lab.
  • Act as an experienced resource, and demonstrate clear and professional verbal and written communication skills.

Your profile

Candidates holding a PhD diploma with a strong background in advanced fluorescence microscopy of live bacteria are encouraged to apply. Experience with SIM, TIRF, PALM, FRAP, FRET, single molecule tracking as well as image analysis is of an advantage. The working language is English.

We offer

Our multidisciplinary group includes microbiologists and structural biologists with an expertise in live-cell imaging, analysis of cell-cell interactions, and understanding of mechanisms involved in the assembly and regulation of a dynamic bacterial nanomachine (a list of recent publications is here). We have an excellent support from various core facilities with expert staff as well as our own state-of-the art equipment, including a super-resolution microscope.

Starting date by arrangement. Long term funding is secured from an ERC consolidator grant. Salary according to SNSF guidelines.

Application / Contact

Please apply online. Upload the following four separate PDF documents:
  1. Your CV with contacts for three references
  2. a brief description of previous research experience (1 page)
  3. Motivation letter explaining why you are a good candidate for this job offer (max 2 pages)
  4. List of all your publications (including pre-prints). For up to three publications most relevant to this job offer describe shortly (up to 200 words) your role as well as why is the publication relevant (for example: what techniques you learned, what experience you gained, etc.).

Incomplete applications will be disregarded. Please apply by 31 August 2022.

For any informal enquiries, please contact: basler-recruitment@unibas.ch.
Apply now