BIPED2 Application Portal

Currently open positions

PhD students – physics of bacterial infections and collective behavior

The Biozentrum of the University of Basel is one of the leading life sciences research institutes in the world. It consists of 30 groups and 500 employees that investigate how molecules and cells create life, spanning the scales from atoms to organisms and communities. The Biozentrum has been the birth place of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

The research group of Prof. Knut Drescher at the Biozentrum of the University of Basel seeks to appoint PhD students in biological physics, with a focus on bacterial infections and bacterial collective behavior, to start immediately or as per arrangement.

The project

The research group of Knut Drescher focuses on understanding the development and functions of bacterial collective behaviors, particularly in the context of human infections, using controlled laboratory experiments and clinical samples. One relevant collective bacterial behavior is the formation of bacterial biofilms, which are antibiotic-tolerant bacterial communities that are the cause of many chronic and acute infections. A separate type of bacterial collective behavior is the formation of bacterial swarms, which can result in a unique type of turbulence, and enhanced spreading across surfaces. Bacterial biofilms and swarms are also model systems for understanding fundamental aspects of collective behaviors in bacteria.

The PhD projects will focus on either bacterial biofilms or swarms, in the context of human infections. The projects will be highly quantitative, and will involve the analysis of big datasets with advanced data analysis and machine learning techniques. The PhD projects require a background in physics, biophysics, mathematics, or a similar discipline. The exact projects are flexible and will be developed together with Knut Drescher, depending on the strengths and interests of the PhD students.

To get an overview of recent projects, take a look at our publications.

Your profile

We are looking for highly motivated and talented PhD students to join our lab. A Master degree in physics, biophysics, applied physics, mathematics, or a similar discipline is required. In addition, an interest in learning about bacterial collective behaviors and bacterial infections is required.

We offer

We offer a highly interactive, multidisciplinary, and international research group within the Biozentrum. Our group spans expertise in physics and molecular biology, as well as bioinformatics and the analysis of big datasets. Moreover, the Biozentrum offers excellent internal support from various core facilities with expert staff, and a structured PhD program. Our group embraces diversity and equal opportunity. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills.

Basel is an international city with people from 150 nations. Located on the border where Switzerland, Germany, and France meet, Basel is home for a large number of institutions for biomedical research, with numerous possibilities for training, networking, and career development. Basel provides a high standard of living and a rich and varied cultural atmosphere.

Application / Contact

Application deadline: 18 March 2022
Please note that only applications through the online form will be accepted.

The application should include a brief statement of your scientific interests, your research experience, and your particular interest in this open position. In addition, a CV and the contact information of two references is required.

For any informal enquiries, please contact: knut.drescher@unibas.ch

Apply now

Scientist/Engineer Cryo-Electron Tomography (CryoET) - BioEM lab at Biozentrum, University of Basel

Starting immediately or upon agreement

The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 30 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birth place of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

We are looking to recruit a highly motivated and enthusiastic specialist in biological CryoET to join the BioEM lab.

Your responsibilities are

  • to prepare samples (plunge-freezing, FIB lamella) for cryoET, operate cryo electron microscopes and support user operation
  • to develop and support tools and software for cryo-ET
  • to analyze and process data for customers and collaborators
  • to support and contribute technological and scientific projects
  • to manage data in collaboration with IT and scientific computing units

Your profile

We are looking for an enthusiastic and goal-oriented person with a completed scientific or engineering degree (Msc/PhD), and expertise in cryoET-based structural biology. You have good knowledge of electron microscopy hardware, and hands-on, in-depth experience in operating cryo-electron microscopes using automation software such as SerialEM and EPU. You have successfully analyzed tomograms and are an experienced user of cryoET analysis software with practical skills in scripting and programming. You like to work in an agile academic work environment and embrace a service-oriented approach. Good communication skills in English are required.

We offer

We offer an exciting and stimulating work environment with state-of-the art equipment and ample opportunities for interactions with academic and industrial partners at the department, in the region and internationally. The position is for 2 years with option for extension. Salary and benefits according to University of Basel standards.

Basel is an international city with people from 150 nations. Located on the border where three countries meet - Switzerland-Germany-France -, it is Europe’s most important life sciences hub. Basel provides a high standard of living and a rich and varied cultural atmosphere.



Application / Contact

The application should include a brief personal statement, explaining how your qualifications and experience relate to the role, together with a full, up-to-date CV and at least two reference letters. Review of applications will start immediately until the position is filled. Please note that only online applications will be considered.

For more information about Biozentrum and the BioEM lab, see www.biozentrum.unibas.ch/bioem/

For further information, please contact mohamed.chami@unibas.ch.
Apply now

Laboratory technician (100%) in the Hall laboratory

Starting from 1 April 2022 or as per agreement

The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 30 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birth place of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

The research group of Michael Hall is looking for a laboratory technician. Main focus of the research is to understand the role of mTOR signaling in growth and metabolism. In particular, we are interested in metabolic alterations in liver cancer and diabetes.

Your responsibilities are

  • to manage and maintain mouse lines
  • to perform in vivo experiments
  • to provide support in cell culture and histology
  • to perform basic protein and nucleic acid techniques such as immunoblotting, (q)PCR, and ELISA

Your profile

You have completed a degree in biology (Bachelor’s/Master’s) or training as a lab assistant/technician. An excellent understanding and experience in transgenic breeding and maintaining of breeding colonies is essential. You have profound experience in mouse handling and injection techniques (experience in IV, IP, and SC injections and PO drug delivery is required). Experiences in metabolic experiments (for example GTT, ITT, and metabolic clamp) and surgery techniques are a plus. Experience in histology is an advantage. You have experience in cell biological techniques (cell culture and downstream biochemical techniques). The successful candidate is highly motivated, eager to acquire new skills, and can work independently in a team environment. Communication skills in oral and written English are essential. Communication skills in German are an advantage. Basic computer skills are desirable.

We offer

We are a highly interdisciplinary, international, divers and supportive team of scientists, committed to work at the frontier of science The Biozentrum offers a cutting-edge research infrastructure and a highly international environment and excellent working conditions. The position is initially for one year, with the possibility of further extension. Salary and benefits according to University of Basel standards.

Basel is an international city with people from 150 nations. Located on the border where three countries meet, Switzerland-Germany-France, it is Europe’s most important life sciences hub. Basel provides a high standard of living and a rich and varied cultural atmosphere.



Application / Contact

The application should include a brief personal statement, explaining how your qualifications and experience relate to the role, together with a full, up-to-date CV, diplomas and at least two reference letters. Review of applications will start immediately until the position is filled. Please note that only online applications will be considered.

For any informal enquiries, please contact: dirk.mossmann@unibas.ch.
Apply now

Postdoctoral Researcher - To study how cells regulate their life span

The Biozentrum of the University of Basel is one of the leading Life Sciences Institutes in the world. It accommodates 30 research groups and 500 employees investigating how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birthplace of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

A postdoctoral position is available in the group of Prof. Jean Pieters at the Biozentrum of the University of Basel.

The Project

The goal of the project is to investigate how cells regulate their life span. Research in the Pieters’ laboratory aims to understand the regulation of cell population homeostasis by members of the coronin protein family within the immune system as well as other physiological systems (see e.g. Pieters et al, Nature Reviews Immunology, PMID 23765056; Vinet et al., Mol. Biol, Cell, PMID 24403600, Jayachandran et al., Immunity, PMID 30611611, Mori et al., Science signaling, 34932374). We use a combination of innovative in vitro and in vivo approaches that cover the entire spectrum from molecules to cells to organisms to unravel the mechanisms underlying the establishment and maintenance of cell population homeostasis. The successful candidate will be able to utilize and develop innovative in vitro, ex vivo and in vivo state-of-the-art experimental systems to study how cell population homeostasis is regulated to achieve proper functioning.

Your profile

The successful candidate should hold a Ph.D. degree and have a strong background in biochemistry, cell biology and molecular biology and ideally be familiar with both in vitro and in vivo techniques; Furthermore, the candidate should exhibit team spirit, be highly motivated, self-driven and creative.

We offer

Our team consists of a dynamic group of scientists with experience spanning from basic biochemistry and cell biology to in vivo modeling of disease. We collaborate with our excellent and state-of-the-art core facilities at the Biozentrum.

Basel is an international city with people from ~150 nations. Located on the border where three countries meet - Switzerland-Germany- France -, it is Europe’s most important life sciences hub. Basel provides a high standard of living and a rich and varied cultural experience.

Application / Contact

Applications should be submitted online and include:
  1. A motivation letter that includes a statement of research interests;
  2. Your CV;
  3. At least two recommendation letters;
  4. A list of all publications (including pre-prints). Also highlight up to three publications as being the most significant achievements describing your role and the impact of the work.

Incomplete applications will be disregarded. Reviewing of applications will start on February 1 and continue until the position is filled.

For any inquiries please contact jean.pieters@unibas.ch.
Apply now

PhD students - molecular microbiology and bacterial biofilms

The Biozentrum of the University of Basel is one of the leading life sciences research institutes in the world. It consists of 30 groups and 500 employees that investigate how molecules and cells create life, spanning the scales from atoms to organisms and communities. The Biozentrum has been the birth place of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

The research group of Prof. Knut Drescher at the Biozentrum of the University of Basel seeks to appoint PhD students in molecular microbiology, with a focus on bacterial biofilms, to start immediately or as per arrangement.

The project

The research group of Knut Drescher focuses on understanding the development and functions of bacterial biofilms, particularly in the context of human infections, using controlled laboratory experiments or clinical samples. Biofilms are antibiotic-tolerant bacterial communities that are the cause of many chronic and acute infections, but biofilms are also a model system for understanding basic aspects of multicellular organization in bacteria. The PhD projects on bacterial biofilms be within the broad set of topics investigated within the research group, and will require a background in molecular microbiology. The exact projects are flexible and will be developed together with Knut Drescher, depending on the strengths and interests of the PhD students.

To get an overview of recent projects, take a look at our publications.

Your profile

We are looking for highly motivated and talented PhD students to join our lab. A Master degree in biology, biochemistry, biotechnology, bioengineering, or a similar discipline is required. In addition, expertise and training in molecular microbiology is required. Knowledge in one or more of the following topics is beneficial: microbial genetics, biochemistry and metabolism, RNA biology, bacteria-host interactions, infection biology.

We offer

We offer a highly interactive, multidisciplinary, and international research group within the Biozentrum. Our group spans expertise in molecular microbiology, biophysics, as well as bioinformatics and the analysis of big datasets. Moreover, the Biozentrum offers excellent internal support from various core facilities with expert staff, and a structured PhD program. Our group embraces diversity and equal opportunity. We are committed to building a team that represents a variety of backgrounds, perspectives, and skills.

Basel is an international city with people from 150 nations. Located on the border where Switzerland, Germany, and France meet, Basel is home for a large number of institutions for biomedical research, with numerous possibilities for training, networking, and career development. Basel provides a high standard of living and a rich and varied cultural atmosphere.

Application / Contact

Application deadline: 25 February 2022
Please note that only applications through the online form will be accepted.

The application should include a brief statement of your scientific interests, your research experience, and your particular interest in this open position. In addition, a CV and the contact information of two references is required.

For any informal enquiries, please contact: knut.drescher@unibas.ch

Apply now

Postdoc Position 100% - Establish a mammalian intestinal organoid system

The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 30 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birthplace of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

Professor Anne Spang (Biozentrum, University Basel) is recruiting a postdoctoral fellow to establish a mammalian intestinal organoid system to study intracellular transport.


The Project

Inter- and intracellular communication is one of the basics of eukaryotic life. Exo- and endocytic transport are essential components for this communication. Most of our knowledge on these communication events stem from either single cell analyses and to a lesser extent from animal model systems. While in the single cell context the influence of neighboring cells is missing, mammalian animal models are very complicated and data hard to interpret. C. elegans is an extremely useful model (Solinger, Rashid et al., Nat. Cell Biol. 2020, Solinger et al., researchsquare). However, its intestinal organization is very simple. To bridge the gap of knowledge, we wish to establish a mammalian intestinal organoid system and study intracellular transport, with an emphasis of the endosomal system.


Your profile

Interested candidates should hold a PhD and have a proven record in cell biology, in particular organoid biology. Experience in CRISPR/Cas9 technology (knock-in and knock-out), live cell imaging and intracellular transport is advantageous. High intrinsic motivation, ability to work independently as well as in a team, perseverance and creativity are expected.


We offer

We are a highly interdisciplinary, international, divers and supportive team of scientists, committed to work at the frontier of science and to solve fundamental questions about cellular function and organization. We offer an interactive environment in which you can broaden your horizon, develop new ideas and your independence, and grow as a scientist and a professional. The Biozentrum of the University of Basel provides a highly stimulating, international and collaborative research environment with state-or-the-art infrastructure and support facilities in a brand-new building.

Basel is an international city with people from 150 nations. Located on the border where Switzerland, Germany, and France meet, Basel is home for a large number of institutions for biomedical research, with numerous possibilities for training, networking and career development. The city provides a high standard of living and a rich and varied cultural atmosphere.


Application / Contact

The application should include a brief personal statement, explaining how your qualifications and experience relate to the role, together with a full, up-to-date CV and at least two reference letters. Review of applications will start immediately. Please note that only online applications will be considered.

For any informal enquiries, please contact anne.spang@unibas.ch
Apply now

Postdoc Position 100% - Structure and function of FERARI tethering complex

The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 30 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birthplace of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

Professor Anne Spang (Biozentrum, University of Basel) is recruiting a postdoctoral fellow to elucidate the structure and function of the FERARI tethering complex.


The Project

Inter- and intracellular communication is one of the basics of eukaryotic life. Exo- and endocytic transport are essential components for this communication. Most of the endoytosed material is returned to the plasma membrane through recycling pathways. We have identified a key regulator of the Rab11 recycling pathway, the tethering complex FERARI (Solinger, Rashid et al. Nat. Cell Biol. 2020). FERARI is an unusual tether as it combines membrane fusion and membrane fission activities to promote kiss-and-run of Rab11-positive recycling vesicles with sorting endosomes. More recently, we also showed that FERARI can also promote kiss-and-run of early endocytic Rab5 positive-vesicles with sorting endosomes (Solinger et al., researchsquare). In order to understand how these processes are regulated and coordinated by FERARI, we aim to determine the structure of the FERARI tethering complex and biochemically elucidate and recapitulate FERARI function in vitro.

This project is supported by a grant from the Swiss National Science Foundation.


Your profile

Interested candidates should hold a PhD and have a proven record in biochemistry and/or structural biology. A background in cell biology and/or cryo EM is advantageous. High intrinsic motivation, ability to work independently as well as in a team, perseverance and creativity are expected.


We offer

We are a highly interdisciplinary, international, divers and supportive team of scientists, committed to work at the frontier of science and to solve fundamental questions about cellular function and organization. We offer an interactive environment in which you can broaden your horizon, develop new ideas and your independence, and grow as a scientist and a professional. The Biozentrum of the University of Basel provides a highly stimulating, international and collaborative research environment with state-or-the-art infrastructure and support facilities in a brand-new building.

Basel is an international city with people from 150 nations. Located on the border where Switzerland, Germany, and France meet, Basel is home for a large number of institutions for biomedical research, with numerous possibilities for training, networking and career development. The city provides a high standard of living and a rich and varied cultural atmosphere.


Application / Contact

The application should include a brief personal statement, explaining how your qualifications and experience relate to the role, together with a full, up-to-date CV and at least two reference letters. Review of applications will start immediately. Please note that only online applications will be considered.

For any informal enquiries, please contact anne.spang@unibas.ch
Apply now

PhD Position – Regulatory mechanisms of mRNA transport and fate in processing bodies

The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 30 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birthplace of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

Professor Anne Spang (Biozentrum, University Basel) is recruiting a PhD student to study the regulatory mechanisms of mRNA transport and fate in processing bodies.

We are a highly interdisciplinary, international, divers and supportive team of scientists, committed to work at the frontier of science and to solve fundamental questions about cellular compartmentalization and organization. The Spang lab is an associated member of the National Center of Competence and Research (NCCR) RNA and Disease.


The Project

Cells respond to stress with remodeling their proteome. As part of this response, translation is attenuated and mRNAs deposited into processing bodies (P-bodies) within 5-10 min, where they can be either stored or decayed (Kilchert et al., 2010, Wang et al., 2018). Depending on the stress, a distinct subset of mRNAs accumulates in P-bodies (Wang et al., 2018). Virtually nothing is known about the decision making that regulates RNA transport or fate in P-bodies. This aim of this project is to provide mechanistic insights into these decision-making processes using state-of-the-art technologies and methods.


Your profile

We are looking for a talented, ambitious and motivated PhD student to join our efforts to understand the regulation of RNA storage and decay under various stress conditions. Experience in live cell imaging, molecular biology, biochemistry and/or RNA biology (RNAseq/Riboseq) is advantageous.


We offer

We offer an interactive environment in which you can broaden your horizon, develop new ideas and your independence, and grow as a scientist and a professional. You will be part of the Biozentrum PhD program, a highly interactive network of the PhD students. The Biozentrum of the University of Basel provides a highly stimulating, international and collaborative research environment with state-or-the-art infrastructure and support facilities in a brand-new building.

Basel is an international city with people from 150 nations. Located on the border where Switzerland, Germany, and France meet, Basel is home for a large number of institutions for biomedical research, with numerous possibilities for training, networking and career development. The city provides a high standard of living and a rich and varied cultural atmosphere.


Application / Contact

The application should include a brief personal statement, explaining how your qualifications and experience relate to the role, together with a full, up-to-date CV and at least two reference letters. Review of applications will start immediately. Please note that only online applications will be considered.

For any informal enquiries, please contact anne.spang@unibas.ch
Apply now

Elektroniker/in (80-100%)

Ab 1. Februar 2022 oder nach Vereinbarung

Das Biozentrum der Universität Basel ist eines der weltweit führenden Institute für Life Sciences. Seine 32 Gruppen und 500 Mitarbeitenden erforschen, wie Moleküle und Zellen Leben erschaffen. Dabei decken sie das ganze Spektrum vom Atom bis zum Organismus ab. Das 1971 gegründete Biozentrum ist Geburtsstätte zahlreicher grundlegender Entdeckungen in Biologie und Medizin und hat mehrere Nobelpreisträger hervorgebracht.

Zur Verstärkung unserer Elektronik-Werkstatt suchen wir per 1. Februar 2022 oder nach Vereinbarung eine/n Elektroniker/in.

Die elektronische Werkstatt kümmert sich um die Wartung und Reparatur der Elektronik- und Laborgeräte. Auf Wunsch der Forschenden werden Geräte auch modifiziert oder je nach Bedürfnis – häufig in Zusammenarbeit mit der mechanischen Werkstatt – Spezialanfertigungen entwickelt. Einhergehend mit dem breiten Spektrum der Forschungsthemen am Biozentrum ist dann auch die Bandbreite der nicht handelsüblichen Geräte und Installationen wie beispielsweise Timer, Schrittmotorsteuerungen, Temperaturregler, Sensorenauswertungen, Verstärker, Heizplatten, Mikroskopkühltischen, Detektoren und vieles mehr.

Ihre Aufgaben

  • Reparaturen und Unterhaltsarbeiten an diversen Laborgeräten
  • Entwicklung und Aufbau elektronischer Geräte nach Vorgaben der Wissenschaftler
  • Unterstützung unserer Wissenschaftler bei Versuchsaufbauten

Ihr Profil

  • Abgeschlossene Berufslehre als Elektroniker EFZ
  • Verantwortungsbewusste, teamfähige und offene Persönlichkeit
  • Hohe Service- und Kundenorientierung, sowie eine selbständige Arbeitsweise
  • Gute Deutsch- und Englischkenntnisse in Wort und Schrift
  • Kenntnisse in der Programmierung (Mikrokontroller, Arduino)
Wir wünschen uns eine Persönlichkeit, die Freude daran hat, als Mitglied eines Teams moderne Forschung möglich zu machen. Sie arbeiten zielgerichtet, vorausschauend und umsichtig? Sie reagieren souverän und flexibel auf die vielfältigen Anforderungen im universitären Forschungsumfeld? Sie haben Freude am Umgang mit Menschen aus aller Welt? Dann sind Sie die Person, die wir suchen.

Wir bieten

Wir bieten Ihnen eine abwechslungsreiche Tätigkeit in einem Zweierteam, sowie zeitgemässe Anstellungsbedingungen und Sozialleistungen im Rahmen der universitären Besoldungsordnung. Diese Stelle ist auf zwei Jahre befristet, mit Option auf Festanstellung nach positiver Evaluation.

Bewerbung

Bitte bewerben Sie sich online mit einem Lebenslauf, einem Motivationsschreiben, Arbeitszeugnissen sowie dem Namen/der Adresse von zwei Referenzen.

Die Bewerbungen werden fortlaufend geprüft, bis die Stelle besetzt ist. Bitte beachten Sie, dass nur Online-Bewerbungen akzeptiert werden.

Weitere Auskunft erteilt Ihnen gerne Herr Simon Saner, Tel. 061 207 04 75, E-Mail: s.saner@unibas.ch.
Apply now

Bioinformatician / Data Analyst (100%)

The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 30 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birthplace of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

A bioinformatics data analyst position is available in the group of Mihaela Zavolan, at the Biozentrum, University of Basel. The group combines high-throughput experimental with computational approaches to study many aspects of RNA processing in the context of processes such as organism aging and cancer development.

The expertise of our group members covers the entire spectrum of biomedical research, from molecular biology to computational tool development, data analysis and software engineering. We recently relocated in a new building in a large and very active life science research park that includes multiple research institutes.

We study how gene expression is regulated in mammalian cells, how it is perturbed in diseases and what key factors are responsible for dysregulation.

We are looking for a talented bioinformatician with extensive experience in transcriptome and proteome data analysis to help us integrate data sets generated in our lab or through collaborative projects.


Your profile

You hold a PhD in bioinformatics, computational biology or related field, and you have strong experience in analyzing sequence data (transcriptomes, proteomes, binding data for RNA-binding proteins or transcription factors).


Your position

You work closely with other members of the group to help analyze and integrate high-throughput data sets, supporting ongoing projects in the group as well as our collaborative projects.


We offer

We are a highly interdisciplinary, international and supportive team of scientists, where you will have the opportunity to broaden your horizons, develop new ideas, and engage other team members in implementing and testing your ideas in experimental systems. At the Biozentrum we have access to state-of-the-art facilities for systems-level interrogation of biological systems and a computational infrastructure to match the demands of big data science. We are also part of the Swiss Institute of Bioinformatics and of the NCCR network “RNA and Disease”. The position is for two years. It is available immediately. The call is open until the position is filled.

Basel is an international city with people from 150 nations. Located on the border where Switzerland, Germany, and France meet, Basel is home for a large number of institutions for biomedical research, with numerous possibilities for training, networking and career development. The city provides a high standard of living and a rich and varied cultural atmosphere.


Application / Contact

The application should include a brief personal statement, explaining how your qualifications and experience relate to the role, together with a full, up-to-date CV and contact information of two references. We will review applications starting November 10, 2021 until the position is filled. In all cases, you will be notified of the outcome of your application. Please note that only online applications will be accepted.

For any informal enquiries, please contact Mihaela Zavolan, e-mail: mihaela.zavolan@unibas.ch

Check out a few of our recent publications

On PolyASite: Herrmann CJ et al, doi 10.1093/nar/gkz918

On Sarkopenia: Börsch A et al, doi 10.1038/s42003-021-01723-z

On Bayesian Inference: Breda J et al, doi 10.1038/s41587-021-00875-x

Apply now

PhD Fellowship in Mechanotransduction and nucleocytoplasmic transport

The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 30 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birthplace of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

Skilled and motivated individuals are encouraged to apply for a 4-year PhD Fellowship in the research group of Roderick Lim at the Biozentrum, University of Basel, Switzerland.


The Lim Lab is interested in understanding how mechanotransduction and nucleocytoplasmic transport (NCT) work in unison to achieve gene expression and cellular phenotypic changes such as during developmental progression, stem cell differentiation and cell transformation.


Your responsibilities

In this project, we want to study how mechanical force impacts on the nuclear pore complexes (NPCs) that mediate NCT. Methods will comprise, amongst others, CRISPR-based genome editing, state-of-the art confocal imaging (including FRET, FRAP, and super-resolution techniques) and atomic force microscopy (AFM).

Besides basic research, PhD candidates will also have to contribute to undergraduate level teaching.


Your profile

Interested candidates should have a background in molecular cell biology, biophysics or related disciplines. Experience in optical/fluorescence imaging or AFM, is a plus. The successful candidate is expected to be highly interactive and capable of independent research in a team environment. A solid command of oral and written English is essential.


We offer

We are a multi-national, interdisciplinary lab that combines biophysical, molecular and cellular approaches to investigate intriguing biological problems. The successful applicant will benefit from a highly stimulating, collaborative research environment as well as state-of-the-art infrastructure and facilities at the new Biozentrum research tower.

Basel is an international city with people from 150 nations. Located on the border where three countries meet - Switzerland-Germany-France - it is Europe’s most important life sciences hub. Basel provides a high standard of living and a rich and varied cultural atmosphere.


Application / Contact

The application should include a cover letter, CV, diplomas and 3 reference letters. Reviewing of applications will start immediately and continue until the position is filled. Please note that only online applications will be accepted.

For further information, please contact stephanie.gehlen@unibas.ch
Apply now

INCATE Test Application

This is the test application for the INCATE program
Apply now

Biozentrum Research Summer 2022: Internships for Bachelor Students

The Biozentrum offers Bachelor Students the opportunity to immerse themselves in real-life science projects. During the "Biozentrum Research Summer 2022" you will spend seven to nine weeks in a Biozentrum Research Group, perform original research under the guidance of experienced scientists and participate in an inspiring scientific and social program. The internship is concluded with a written report on your research progresses. By the end of your time in Basel, you will have the chance to present your results to the Biozentrum community as a speaker of the Research Summer Symposium. The internship is open to Bachelor Students in Biology, Nanosciences, Chemistry, Physics, Computational Sciences and related fields.

Important note

To be able to participate in the research summer, the selected students will be required to have a valid Swiss COVID certificate (or accepted international equivalent) for the duration of their internship. Further rules may apply as required by the Swiss federal authorities.

Apply now

EMBO Workshop: New Approaches to Combat Antibiotic-Resistant Bacteria - Pre-registration

Description

Scientific Organizers

Priscille Brodin, Christoph Dehio, Sophie Helaine, and Laurence van Melderen

Date

June 12-16, 2022

Location

Ascona, Switzerland

Summary of the meeting

Although the COVID-19 pandemic has claimed the headlines the past two years, bacterial infections represent an urgent and ever growing threat to human health worldwide. Over the past decades, pan-resistant strains of major bacterial pathogens have emerged rendering clinically available antibiotics ineffective. As a result, many achievements of modern medicine are now at risk. New ways to identify clinically effective antimicrobials are urgently needed to counter this threat. However, the current antimicrobial development pipeline is insufficient because of high attrition rates and limited coverage of multi-drug resistant Gram-negative bacteria. This conference aligns with the scope of the National Center of Competence in Research “AntiResist” which aims at revitalizing antibiotic discovery by bringing a patient-centered paradigm shift. Such a shift requires a multidisciplinary approach starting at the bedside. This EMBO workshop bids to review the current knowledge on bacterial physiology in patients, outline the development of relevant in-vitro models to study the underlying molecular mechanisms and provide an overview of novel intervention strategies. Bringing together the world’s foremost scientists in the field of antimicrobial research will help close the gap between the bedside and the bench and will enable to accelerate the clinical development of new antimicrobial therapies to win the race against superbugs.

Contact

For more information about the conference program, venue, financial assistance, and important deadlines, visit the conference website. For specific questions regarding the registration or financial assistance, contact nacarb2022-bz@unibas.ch

Apply now

NCCR AntiResist Fellowship Call 2022

Excellent students from all over the world are encouraged to apply for the Fellowship in Antibiotic Discovery by the NCCR AntiResist.

NCCR AntiResist fellowships provide successful applicants with funding for 3 years and rotation-based selection of their research group of choice within the consortium. Fellows will be part of a vibrant community of PhD students with educational benefits ranging from cross-disciplinary research projects and tutoring to hands-on teaching in state-of-the art technology and joint summer schools.

Apply now

NCCR AntiResist Bridging Project 2022

Description

A bridging project brings together 2 labs with specific expertise around a single research project. Bridging projects need to have an interdisciplinary character; they must either integrate knowledge and methods from different disciplines or integrate complementary technologies from the same discipline. The project should be tailored to a PhD student that is engaged in the project: s/he is the bridge, and hence the project needs to be aligned with the educational mission of the NCCR with the aim of training students in different fields of research. A bridging project is not a project to help fulfill existing milestones.

Your profile

The main applicant must be a group leader and a member of NCCR AntiResist. S/he will be the contact point for the PhD student.

The co-applicant can be a group leader/project leader/research associate/postdoctoral fellow from a different lab, which is part of or associated with NCCR AntiResist. Each group leader can submit one proposal as a main applicant, and an unlimited number of projects as a co-applicant.

Selection criteria

The reviewers will comment on specific aspects of the proposal, including, but not limited to collaboration, originality, innovation, impact, feasibility, and education.

  • COLLABORATION:
    How collaborative is the project? i.e., to what extent is its bridging nature required for its success? What is the added value of a collaboration?
  • ORIGINALITY and INNOVATION:
    How original, novel or out-of-the-box is the project? Is it outside of ongoing projects covered by the milestones? Does it address a forward-thinking/innovative/cutting-edge scientific question, which is in line with the overall goals of NCCR AntiResist?
  • IMPACT and FEASIBILITY:
    How does the project impact the overall development of NCCR AntiResist? i.e., does the project contribute to achieving our scientific mission and how well integrated it is within the NCCR? To what extent is it high risk/high gain?
  • EDUCATION:
    How well is the project aligned with the educational mission of our NCCR in educating a future generation of scientists across scientific disciplines? Applicants should specifically refer to the goals defined in the strategy paper on Education & Training.

Selection process

All group leaders of the NCCR can view and rate the applications. Rating is mandatory for members of the steering committee. Each project will be given a rating from A to D (A = very strong; should be funded; B = strong; maybe funded; C = weak; rather not funded; D = not suitable; no funding).
Ratings must be supported by specific comments about different aspects of the proposals, including, but not limited to collaboration, originality, innovation, impact, feasibility, and education. All projects that have received at least one top vote (A) will be discussed by the steering committee, and up to 12 to 15 projects will be shortlisted. Shortlisted projects will be presented to the steering committee as well as to the group leaders that participated in the rating. A five-minute presentation of the project by the main applicant will be followed by 10 minutes of questions and discussion with the main applicant and co-applicant. A maximum of 6 projects will be selected and funded. The successful applicants are free to select a PhD student that will be working on the bridging project.

Timeline

Application deadline: January 31, 2022
Review/rating deadline: February 15, 2022
Selection of the projects by the steering committee: Fourth week of February, 2022
Oral Presentations: Fourth week of March, 2022
Decision: March 25, 2022

Contact

For specific questions, feel free to contact Julie Sollier

Apply now