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Currently open positions

ERC-funded PhD positions available on the function and regulation of RNA-containing membrane-less organelles

The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 30 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birthplace of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

Two PhD student positions are available in the laboratory of Prof. Maria Hondele at the Biozentrum, University of Basel, Switzerland.

The Hondele lab studies the formation, function and regulation of RNA-containing membraneless organelles such as stress granules or nuclear speckles. To decipher these processes, we use a combination of biophysics, biochemical reconstitutions, imaging, cell biology, screening and ‘omics’ approaches, with human cell culture and yeast as model organisms. We love to collaborate to integrate structural biology and microfluidics approaches.

Your profile

We are looking for highly motivated, creative individuals who want to dissect fundamental questions in molecular, cellular and systems biology. The successful candidates will have the responsibility and freedom to shape, lead and present their research project.

You should have finished your masters in biology, chemistry or physics by the start of the PhD project; exceptional candidates with a 4 year bachelor will also be considered.

We offer

We are an interdisciplinary and international young team of enthusiastic scientists. We have generous access to state-of-the-art equipment and outstanding support by our in-house facilities. As a PhD student, you will be part of the Biozentrum Graduate Teaching program.
English is our working language; knowledge of German is not required.

Application / Contact

Applications should contain a statement of motivation, ideally including a brief description of your ‘dream research project’ in our lab, a detailed CV (including grades / transcripts), and contact details for at least two references.

For any informal enquiries, please contact: Maria Hondele (maria.hondele@unibas.ch).

A first round of evaluation will be concluded by February 1st; the application platform remains open until the positions are filled. Another graduate student position will be available in summer / fall of 2021.

We look forward to hearing from you!

Apply now

Postdoctoral position on the function and regulation of RNA-containing membrane-less organelles

The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 30 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birthplace of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

A postdoctoral position is available in the laboratory of Prof. Maria Hondele at the Biozentrum, University of Basel, Switzerland.

The Hondele lab studies the formation, function and regulation of RNA-containing membraneless organelles such as stress granules or nuclear speckles. To decipher these processes, we use a combination of biophysics, biochemical reconstitutions, imaging, cell biology, screening and ‘omics’ approaches, with human cell culture and yeast as model organisms. We love to collaborate to integrate structural biology and microfluidics approaches.

Your profile

We are looking for a highly motivated, creative scientist who wants to dissect fundamental questions in molecular, cellular and systems biology. The successful candidate will have the responsibility and freedom to shape, lead and present their research project.

Applicants should have a strong publication record and wish to pursue an academic career. Candidates with a background in the design, generation and analysis of next generation sequencing, mass spectrometry or quantitative microscopy data are especially encouraged to apply.

We offer

We are an interdisciplinary and international young team of enthusiastic scientists. We have generous access to state-of-the-art equipment and outstanding support by our in-house facilities. English is our working language; knowledge of German is not required.

Application / Contact

Applications should contain a statement of motivation, ideally including a brief description of your ‘dream research project’ in our lab, a detailed CV and contact details for at least two references.

For any informal enquiries, please contact: Maria Hondele (maria.hondele@unibas.ch).

A first round of evaluation will be concluded by February 1st; the application platform remains open until the position is filled. The starting date is flexible but would ideally be spring 2021. Another postdoctoral position will be available in summer / fall 2021.

We look forward to hearing from you!

Apply now

Postdoctoral Fellow (100%) to work on mechanisms and treatment options for muscular dystrophies

The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 30 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birthplace of many fundamental discov¬eries in biology and medicine, spawning several Nobel Laureates.

A postdoctoral position is available in the group of Prof. Markus Rüegg at the Biozentrum, University of Basel .

Muscular dystrophies are rare genetic diseases characterized by severe muscle damage caused by the inability of muscle fibers to sustain the mechanical forces generated during contraction. The available position is part of an international research effort aimed to characterize the cellular composition of muscle and their associated stem cells during disease progression and regeneration. Mouse models for distinct muscular dystrophies and patient biopsies will be used. In particular, mouse models for LAMA2 MD/MDC1A will be investigated (see: Reinhard et al., (2017). Sci. Transl. Med. 9.; Yurchenco et al., (2018). Matrix Biol. 71-72, 174-187). The project will use single cell and single nuclei-based transcriptomics and proteomics in conjunction with state-of-the-art computational data analysis.

Your profile

We are looking for candidates with a Ph.D. in molecular biology, biochemistry or neurobiology and a strong background using “omics” technologies. Applicants should be well-trained in advanced cell and molecular biology, have a track record of strong publications and be committed to a career in science. Experience working with mice and the neuromuscular system is a strong plus.

We offer

The project is funded for 3 years; salaries are according to the guidelines of the Swiss National Science Foun¬dation. Our team and the interactive, highly innovative nature of the Biozentrum and of Life Science in Basel provide a stimulating environment that offers all the possibilities to be creative and highly productive. Basel is a city that provides a high standard of living and offers all the advantages of an international community.

Application / Contact

Please apply online with a CV, letter of motivation and contact information for two references.

Reviewing of applications will start immediately and continue until the position is filled.

For any informal enquiries, please contact: Markus Rüegg (markus-a.ruegg@unibas.ch).

Apply now

Postdoctoral researcher – Brucella physiology in clinical human samples (100%)

The Biozentrum of the University of Basel is one of the leading Life Sciences Institutes in the world. It accommodates 30 research groups and 500 employees investigating how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birthplace of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

A postdoc position is available in the group of Prof. Christoph Dehio (www.biozentrum.unibas.ch/dehio)

The advertised position is part of the National Center of Competence in Research AntiResist (2020-2032; https://nccr-antiresist.ch/). NCCR AntiResist is a Swiss-wide interdisciplinary center for antibiotic research with strong collaborations between biologists, clinicians, engineers, computational scientists and chemists. Our goals are to develop relevant laboratory models mimicking Brucella infection and the response to antibiotics in human patients, and to use these models to discover innovative strategies for combating human brucellosis. At the core of this venture are direct links between basic and clinical research and bioengineering.

Your responsibilities are

To develop innovative approaches to isolate and analyze Brucella and Brucella-infected cells from human patient samples in order to better understand the pathogen-host interaction and associated cellular physiological processes on both the host and bacterial side. The gained knowledge will then be used for refining or developing new in-vitro infection models to better study Brucella-host interaction and the resilience to antibiotics.

Your profile

You obtained a PhD in immunology, cell biology, clinical microbiology, or a related field. You have a genuine interest in bacterial-host interaction and in method development. Experience in immunophenotyping and related FACS-based application as well as with analysis from large MS or RNA-seq dataset would be an asset. Willingness to work at Biosafety Level 3 for follow-up experiments would also be a great advantage.

We offer

Our multidisciplinary group includes microbiologists and cell biologist with an expertise in bacterial pathogenesis of zoonosis with chronic manifestations (a list of recent publications can be found here. We have an excellent support from various core facilities with expert staff as well as a very strong multi-disciplinary collaborative environment within the frame of the NCCR AntiResist project.

The position will start in January 2021 or upon agreement and the funding is available for at least three years.

Basel is an international city with people from 150 nations. Located on the border where three countries meet - Switzerland-Germany- France -, it is Europe’s most important life sciences hub. Basel provides a high standard of living and a rich and varied cultural atmosphere.

Application / Contact

Please apply online; only on-line applications will be reviewed. Upload the following three separate PDF documents: 1) Your CV with contacts for three references 2) Motivation letter explaining why you are a good candidate for this job offer 3) List of all your publications (including pre-prints). For up to three publications most relevant to this job offer describe shortly (up to 200 words) your role as well as why is the publication relevant (for example: what techniques you learned, what experience you gained, etc.).

Incomplete applications will be disregarded. Reviewing of applications will begin on Nov 30, 2020 and continue until the position is filled. For general inquiries please send an e-mail to recruitment@nccr-antiresist.ch.

Apply now

Postdoctoral researcher – Postdoctoral researcher – Molecular basis of Brucella type-IV-secretion effector delivery into host cells (100%

The Biozentrum of the University of Basel is one of the leading Life Sciences Institutes in the world. It accommodates 30 research groups and 500 employees investigating how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birthplace of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

A postdoc position is available in the research group of Prof. Christoph Dehio (www.biozentrum.unibas.ch/dehio).

We are interested in the molecular basis underlying pathogenicity of Brucella with a specific interest on its type IV secretion (T4S) system and associated effector proteins. Our goals are to resolve the molecular basis of Brucella T4S-dependent effector secretion by establishing new approaches to address this fundamental question.

Your responsibilities are

While the panel of published effectors translocated by Brucella has recently expended, essential aspects of the translocation process remain elusive. In this context, your goal will be to develop innovative approaches to study the molecular basis of Brucella T4S effector secretion into host cells, by combining the use of surrogate models and work under Biosafety Level 3 (BSL3) conditions. The project will include development of new genetic tools and reporters, biochemical characterization of interaction partners and establishment of new screening methods to identify new effector proteins.

Your profile

You obtained a PhD in, microbiology, synthetic biology or a related research field. You have experience with bacterial secretion system(s) and a genuine interest in bacterial-host interaction. You are creative and willing to contribute to the development of innovative research tools to uncover the molecular mechanism underlying effector translocation by Brucella T4S.

We offer

Our multidisciplinary group includes microbiologists and cell biologist with an expertise in bacterial pathogenesis of zoonosis with chronic manifestations, with a special focus on T4S systems and effectors (a list of recent publications can be found here. We have an excellent support from various core facilities with expert staff as well as a very strong multi-disciplinary collaborative environment.

The position will start in January 2021 or upon agreement and the funding will be available for at least three years.

Basel is an international city with people from 150 nations. Located on the border where three countries meet - Switzerland-Germany- France -, it is Europe’s most important life sciences hub. Basel provides a high standard of living and a rich and varied cultural atmosphere.

Application / Contact

Please apply online; only on-line applications will be reviewed. Upload at least the following three separate PDF documents: 1) your CV with contacts for three references, 2) a motivation letter explaining why you are a good candidate for this job offer and 3) a list of all your publications (including pre-prints). For up to three publications most relevant to this job offer, describe shortly (up to 200 words) your role as well as why is the publication relevant to this position.

Incomplete applications will be disregarded. Reviewing of applications will begin on Nov 30, 2020 and continue until the position is filled.. For general inquiries please send an e-mail to christoph.dehio@unibas.ch.

Apply now

Biozentrum Research Summer 2021: Internships for Bachelor Students

The Biozentrum offers Bachelor Students the opportunity to immerse themselves in real-life science projects. During the "Biozentrum Research Summer 2021" you will spend seven to nine weeks in a Biozentrum Research Group, perform original research under the guidance of experienced scientists and participate in an inspiring scientific and social program. The internship is open to Bachelor Students in Biology, Nanosciences, Chemistry, Physics, Computational Sciences and related fields.
Apply now