BIPED2 Application Portal

Currently open positions

Postdoctoral position (100%, funded) in skeletal muscle plasticity (group of Prof. Christoph Handschin, Biozentrum/University of Basel)

The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 30 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birth place of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

The project

In an interdisciplinary project supported by a Sinergia grant of the Swiss National Science Foundation, we will investigate the molecular underpinnings of gene regulation in muscle plasticity. Thus, in close collaboration with the group of Prof. Sebastian Hiller, comprehensive analysis of RNA-binding, liquid-liquid phase separated condensate formation of transcriptional regulators, coupled to the elucidation of the corresponding structure-function aspects will be performed using various state-of-the-art technologies, spanning from molecular biology to animal (patho)physiology. We are therefore looking for a motivated and well-trained Postdoc to join the multidisciplinary team of postdocs and PhD students from the Handschin and Hiller groups performing these studies in close collaboration and constant exchange.

Your profile

Postdoctoral applicants should have a PhD or MD/PhD. A strong background in molecular and cell biology is required. Experience in RNA-binding protein biology, liquid-liquid phase separation, NGS-based techniques and analysis (e.g. CLIP or ChIPseq), or proteomics of protein complexes and PTMs is ideal. Selection will furthermore be based on the educational background, motivation, independence and creativity of the applicant. Good knowledge of English is a requirement. The positions are funded and salaries according to institutional guidelines.

We offer

Our international team consists of a dynamic and collaborative group of scientists, committed to work at the frontier of science and to solve fundamental questions about muscle plasticity. Successful applicants will be embedded at the interface of the Handschin and Hiller groups. The Biozentrum provides a highly stimulating collaborative research environment with a fantastic infrastructure in a brand-new building. Further, we have access to state-of-the-art technology platforms providing the lab with an optimal environment for carrying out cutting-edge interdisciplinary research.

Basel is an international city with people from 150 nations. Located on the border where three countries meet - Switzerland-Germany- France -, it is Europe’s most important life sciences hub. Basel provides a high standard of living and a rich and varied cultural atmosphere.

Application / Contact

Please apply online, enter the relevant information and upload the required PDF documents, including:
  1. Your up-to-date CV with contact details of at least two referees
  2. A brief personal statement, explaining how your research skills and interests align with the aims of this project and the research focus of our group (max 2 pages)
  3. All required diplomas, including PhD and MSc confirmation and grades
  4. List of all your publications and describe briefly (max 300 words) for up to 3 publications what was your role and why they are relevant for the job offer

Review of applications will start immediately and continue until the position is filled.

For any informal enquiries, please contact: christoph.handschin@unibas.ch
Apply now

PhD student position (100%, funded) in skeletal muscle plasticity (group of Prof. Christoph Handschin, Biozentrum/University of Basel)

The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 30 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birth place of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

The project

In an interdisciplinary project supported by a Sinergia grant of the Swiss National Science Foundation, we will investigate the molecular underpinnings of gene regulation in muscle plasticity. Thus, in close collaboration with the group of Prof. Sebastian Hiller, comprehensive analysis of RNA-binding, liquid-liquid phase separated condensate formation of transcriptional regulators, coupled to the elucidation of the corresponding structure-function aspects will be performed using various state-of-the-art technologies, spanning from molecular biology to animal (patho)physiology. We are therefore looking for a motivated and well-trained Phd to join the multidisciplinary team of postdocs and PhD students from the Handschin and Hiller groups performing these studies in close collaboration and constant exchange.

Your profile

PhD student applicants should have a MSc or equivalent degree. A strong background in molecular and cell biology is required. Experience in RNA-binding protein biology, liquid-liquid phase separation, NGS-based techniques and analysis (e.g. CLIP or ChIPseq), or proteomics of protein complexes and PTMs is ideal. Selection will furthermore be based on the educational background, motivation, independence and creativity of the applicant. Good knowledge of English is a requirement. The positions are funded and salaries according to institutional guidelines.

We offer

Our international team consists of a dynamic and collaborative group of scientists, committed to work at the frontier of science and to solve fundamental questions about muscle plasticity. Successful applicants will be embedded at the interface of the Handschin and Hiller groups. The Biozentrum provides a highly stimulating collaborative research environment with a fantastic infrastructure in a brand-new building. Further, we have access to state-of-the-art technology platforms providing the lab with an optimal environment for carrying out cutting-edge interdisciplinary research.

Basel is an international city with people from 150 nations. Located on the border where three countries meet - Switzerland-Germany- France -, it is Europe’s most important life sciences hub. Basel provides a high standard of living and a rich and varied cultural atmosphere.

Application / Contact

Please apply online, enter the relevant information and upload the required PDF documents, including:
  1. Your up-to-date CV with contact details of at least two referees
  2. A brief personal statement, explaining how your research skills and interests align with the aims of this project and the research focus of our group (max 2 pages)
  3. All required diplomas, including MSc confirmation and grades

Review of applications will start immediately and continue until the position is filled.

For any informal enquiries, please contact: christoph.handschin@unibas.ch
Apply now

PhD position in structural bioinformatics of viral proteins

The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 32 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birth place of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

In Prof. Torsten Schwede’s group, we use computational methods to model protein structures, characterise protein-ligand interactions, and explore the effects of mutations on protein structure and function. We also explore the application of AI methods to characterise the viral and dark proteome, and to automate areas of discovery and design of novel therapeutics. Within the SIB Swiss Institute of Bioinformatics, we develop SWISS-MODEL (https://swissmodel.expasy.org), a widely used web-based platform for generating high-accuracy 3D models of protein structures and complexes for application in life sciences.

The project

The project involves identifying regions in viral proteins that can be leveraged to disrupt pathogenic mechanisms. The successful PhD candidate will use cutting-edge computational techniques to model structures of large viral protein complexes, and analyse their conformational flexibility as well as variations within patient samples. In addition, the candidate will apply surface-centric approaches to discover epitope-like regions that can be exploited for the development of antiviral mRNA and protein-based strategies.

Current structure prediction and analysis techniques are not yet readily applicable to viral proteins due to their unique properties. For example, their sequence diversity far exceeds other kingdoms, highlighting their fast evolutionary rates. They often contain functionally-relevant intrinsically disordered regions, and tend to assemble into large complexes with the surfaces of the complex differing from its constituents.

The research will include active collaboration with experimental groups both in academic and clinical settings, primarily with Prof. Hans H. Hirsch at the University Hospital Basel, on rational protein engineering of therapeutics such as mRNA-based vaccines and antibody design.

Your profile

  • Master in biochemistry, bioinformatics or a related discipline, and a strong interest in structural biology and modern data analytics techniques, AI / ML.
  • You can strengthen our team in at least one of the following areas: protein bioinformatics, viral biology, data science.
  • Good communication skills in English.
  • Self-motivation, drive and ability to explore new research directions.

We offer

The salary is in accordance with the guidelines of the Swiss National Science Foundation.

Basel is a cosmopolitan and multicultural city at the heart of Europe. Bordering three countries, Switzerland, Germany, and France, Basel provides a high standard of living with a thriving cultural atmosphere. The Basel area is Europe’s most important Life Science hub with many small and medium-size biotech companies as well as global pharmaceutical players.

Application / contact

Please apply online and provide a motivation statement that describes how your background and scientific interests match the criteria for this position, CV, and contact information for two references.

Review of applications will begin immediately and proceed until the position has been filled. Early application is strongly encouraged.

The start date is by mutual arrangement, with the possibility to start immediately.

Apply now

Computational Chemist (80%-100%)

Starting from 1 February 2023 or as per agreement

The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 32 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birth place of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

The project

The research group of Timm Maier is looking for a Computational Chemist. Main focus of the research is to understand the structure and function of large regulatory assemblies, such as the mammalian target-of-rapamycin (mTOR) complex. This position is linked to a translational project to discover and develop small molecule inhibitors for novel therapies.

Your responsibilities are

  • Molecular modeling and docking
  • Structure- and ligand-based drug design
  • Virtual screening
  • Communication with Contract Research Organizations CROs and Medicinal Chemistry collaborators

Your profile

  • You have a Ph.D. in Computational Chemistry or related field with a strong background in Computer Aided Drug Design (CADD).
  • At least two year post MSc experience in small molecule drug discovery projects applying computational chemistry tools.
  • Excellent oral and written communication skills, and the ability to work in a multidisciplinary, collaborative team.

We offer

We are a highly interdisciplinary, international, diverse and supportive team of scientists, committed to work at the frontier of science. The Biozentrum offers a cutting-edge research infrastructure and a highly international environment and excellent working conditions. The position is initially for one year, with the possibility of further extension. Salary and benefits according to University of Basel standards.

Basel is an international city with people from 150 nations. Located on the border where three countries meet, Switzerland-Germany-France, it is Europe’s most important life sciences hub. Basel provides a high standard of living and a rich and varied cultural atmosphere.



Application

The application should include a brief personal statement, explaining your motivation for joining this project and your qualifications and experience related to the role, together with a full, up-to-date CV, diplomas and names and addresses of at least two references. Review of applications will start immediately until the position is filled. Please note that only online applications will be considered.

For any informal enquiries, please contact Prof. Timm Maier (timm.maier@unibas.ch) with reference to "Position Computational Chemist".
Apply now

Biozentrum Research Summer 2023: Internships for Bachelor Students

The Biozentrum offers Bachelor Students the opportunity to immerse themselves in real-life science projects. During the "Biozentrum Research Summer 2023" you will spend seven to nine weeks in a Biozentrum Research Group, perform original research under the guidance of experienced scientists and participate in an inspiring scientific and social program. The internship is concluded with a written report on your research progresses. By the end of your time in Basel, you will have the chance to present your results to the Biozentrum community as a speaker of the Research Summer Symposium. The internship is open to Bachelor Students in Biology, Nanosciences, Chemistry, Physics, Computational Sciences and related fields. The program is open to students with a Swiss or EU citizenship as well as holders of a Swiss C-permit.

Apply now