BIPED2 Application Portal

The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 30 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birthplace of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

Skilled and motivated individuals are encouraged to apply for a 4-year PhD Fellowship in the research group of Roderick Lim at the Biozentrum, University of Basel, Switzerland.

The Lim Lab is interested in understanding how mechanotransduction and nucleocytoplasmic transport (NCT) work in unison to achieve gene expression and cellular phenotypic changes such as during developmental progression, stem cell differentiation and cell transformation.

Your responsibilities

In this project, we want to study how mechanical force impacts on the nuclear pore complexes (NPCs) that mediate NCT. Methods will comprise, amongst others, CRISPR-based genome editing, state-of-the art confocal imaging (including FRET, FRAP, and super-resolution techniques) and atomic force microscopy (AFM).

Besides basic research, PhD candidates will also have to contribute to undergraduate level teaching.

Your profile

Interested candidates should have a background in molecular cell biology, biophysics or related disciplines. Experience in optical/fluorescence imaging or AFM, is a plus. The successful candidate is expected to be highly interactive and capable of independent research in a team environment. A solid command of oral and written English is essential.

We offer

We are a multi-national, interdisciplinary lab that combines biophysical, molecular and cellular approaches to investigate intriguing biological problems. The successful applicant will benefit from a highly stimulating, collaborative research environment as well as state-of-the-art infrastructure and facilities at the new Biozentrum research tower.

Basel is an international city with people from 150 nations. Located on the border where three countries meet - Switzerland-Germany-France - it is Europe’s most important life sciences hub. Basel provides a high standard of living and a rich and varied cultural atmosphere.

Application / Contact

The application should include a cover letter, CV, diplomas and 3 reference letters. Reviewing of applications will start immediately and continue until the position is filled. Please note that only online applications will be accepted.

For further information, please contact stephanie.gehlen@unibas.ch

Ab 1. Januar 2022 oder nach Vereinbarung

Das Biozentrum der Universität Basel ist eines der weltweit führenden Institute für Life Sciences. Seine 32 Gruppen und 500 Mitarbeitenden erforschen, wie Moleküle und Zellen Leben erschaffen. Dabei decken sie das ganze Spektrum vom Atom bis zum Organismus ab. Das 1971 gegründete Biozentrum ist Geburtsstätte zahlreicher grundlegender Entdeckungen in Biologie und Medizin und hat mehrere Nobelpreisträger hervorgebracht.

Wir suchen eine administrative Assistentin / einen administrativen Assistenten mit einer starken Einbindung in die Koordination und Administration der Forschungstätigkeit (Lab Manager) für zwei Forschungsgruppen mit einem Beschäftigungsgrad von 60%.

Zu Ihren Aufgaben gehören

• Unterstützung der Forschungsgruppenleiter in administrativen und organisatorischen Belangen
• Unterstützung bei der Personal- und Finanzadministration, Planung des Bestellwesens
• Unterstützung bei Gesuchen (Einreichung, Reporting), Administration und Koordination verschiedener interner und externer Forschungsdatenbanken
• Planung und Koordination der Laborinfrastruktur und des Geräteparks
• Verwalten von Lehrveranstaltungen und Lehrmaterialien mittels Online-System, Organisation von Vorträgen und Konferenzen

Ihr Profil

• Hochschulabschluss in den Naturwissenschaften und Erfahrung in Forschung oder Verwaltung, oder eine abgeschlossene kaufmännische Ausbildung mit mehrjähriger Praxis, bevorzugt im universitären Umfeld
• Ausgezeichnete Deutsch- und Englischkenntnisse in Wort und Schrift
• Hohe Kompetenz im Einsatz von modernen Kommunikationsmitteln
• Sicherer Umgang mit Office Software

Wir wünschen uns eine Persönlichkeit, die Freude daran hat, als Mitglied eines wissenschaftlichen Teams moderne Forschung möglich zu machen. Sie arbeiten zielgerichtet, vorausschauend und umsichtig? Sie reagieren souverän und flexibel auf die vielfältigen Anforderungen im universitären Forschungsumfeld? Sie haben Freude am Umgang mit Menschen aus aller Welt? Dann sind Sie die Person, die wir suchen.

Wir bieten

Wir bieten Ihnen eine abwechslungsreiche Tätigkeit als aktives Mitglied unserer Forschungsgruppen, sowie zeitgemässe Anstellungsbedingungen und Sozialleistungen im Rahmen der universitären Besoldungsordnung. Diese Stelle ist auf zwei Jahre befristet, mit Option auf Festanstellung nach positiver Evaluation.

Bewerbung

Bitte bewerben Sie sich online mit einem Lebenslauf, einem Motivationsschreiben, Arbeitszeugnissen sowie dem Namen/der Adresse von zwei Referenzen.

Die Bewerbungen werden fortlaufend geprüft, bis die Stelle besetzt ist. Bitte beachten Sie, dass nur Online-Bewerbungen akzeptiert werden.

Weitere Auskunft erteilt Ihnen gerne Frau Manuela Holzer, HR Biozentrum, Tel. 061 207 20 22, E-Mail: manuela.holzer@unibas.ch.

The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 30 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birthplace of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

A three-year postdoctoral position is available at the Biozentrum (Basel, Switzerland) in the context of a SNF project led by Dr. Thomas Julou. The position is embedded in the group of Prof. Erik van Nimwegen and the starting date is flexible, between September 2021 and January 2022. The postdoctoral fellow will be supervised by T. Julou and E. van Nimwegen.

The van Nimwegen Lab at Basel University’s Biozentrum is an international and multidisciplinary team with extensive expertise in the field of transcription regulation, cell-to-cell variability, genome evolution, and probabilistic data analysis techniques. A special feature of our group is that it includes both experimental and theoretical researchers which work together to combine cutting edge statistical and computational tools with quantitative experiments. A list of our group's publications can be found on Google Scholar

Your position

The topic of this project concerns Escherichia coli during stationary phase, as a case study of non-growing bacteria. Although bacteria in the wild likely spend the majority of their time in non-growing states, relatively little is known about cell physiology and gene expression in such states, especially at the single-cell level. Our lab uses novel quantitative approaches, such as the one we recently developed to quantitatively track growth and gene expression with single-cell resolution in bacteria exposed to controlled environmental changes [1, 2]. We are interested in both physiological and evolutionary aspects of stationary phase: What are the different physiological states that can be attained during stationary phase? What is the extent and dynamics of cell heterogeneity during stationary, and how does this heterogeneity affect survival, stress-resistance, and the ability of cells to regrow when exposed to new nutrients? Are there evolutionary trade-off(s) between growth-related traits and starvation-related traits? To answer such questions, the candidate is expected to combine experimental techniques from molecular biology, genetics, video-microscopy, microfluidics and microfabrication, with cutting-edge data analysis and modelling techniques, which may be undertaken in collaboration with theoretical researchers in the lab. The project will be tailored to the interests and skills of the successful candidate, and will take advantage of results already obtained by a PhD student in our group.

Your profile

Applicants should have completed a PhD in a relevant field such as biophysics, quantitative biology, microbiology, or evolution. Previous experience with microscopy and microfluidics will be valued. Experience with quantitative analysis and programming skills are a plus as well.

Application / Contact

The application should include a CV and motivation statement as well as the contact details of at least two references. Reviewing of applications will start immediately and continue until the position is filled. Please note that only online applications will be accepted.

For specific questions, feel free to contact Thomas Julou, e-mail: thomas.julou@unibas.ch

This is the test application for the INCATE program

Excellent students from all over the world are encouraged to apply for the prestigious "Biozentrum PhD Fellowships" program.

The aim of the fellowships which are sponsored by the Werner Siemens-Foundation and the University of Basel is to select and promote highly talented graduate students in the area of Life Sciences. The fellowships offer direct access to the PhD program of the Biozentrum, University of Basel, additional financial support, a rotation-based selection of the research group, and support for the attendance of scientific meetings and courses during the PhD.