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Currently open positions

Postdoctoral Fellow (100%) to work on mechanisms and treatment options for muscular dystrophies

The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 30 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birth place of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

A postdoctoral position is available in the group of Prof. Markus Rüegg at the Biozentrum, University of Basel .

Muscular dystrophies are rare genetic diseases characterized by severe muscle damage caused by the inability of muscle fibers to sustain the mechanical forces generated during contraction. The available position is part of an international research effort aimed to characterize the cellular composition of muscle during disease progression. Mouse models for distinct muscular dystrophies and patient biopsies will be used. In particular, mouse models for LAMA2 MD/MDC1A will be investigated (see: Reinhard et al., (2017). Sci. Transl. Med. 9.; Yurchenco et al., (2018). Matrix Biol. 71-72, 174-187). The project will use single cell-based transcriptomics and proteomics in conjunction with state-of-the-art computational data analysis.

Your profile

We are looking for candidates with a Ph.D. in molecular biology, biochemistry or neurobiology and a strong background using “omics” technologies. Applicants should be well-trained in advanced cell and molecular biology, have a track record of strong publications and be committed to a career in science. Experience working with mice and the neuromuscular system is a strong plus.

We offer

The project is funded for 3 years; salaries are according to the guidelines of the Swiss National Science Foundation. Our team and the interactive, highly innovative nature of the Biozentrum and of Life Science in Basel provide a stimulating environment that offers all the possibilities to be creative and highly productive. Basel is a city that provides a high standard of living and offers all the advantages of an international community.

Application / Contact

Please apply online with a CV, letter of motivation and contact information for two references.

Reviewing of applications will start immediately and continue until the position is filled.

For any informal enquiries, please contact: Markus Rüegg (markus-a.ruegg@unibas.ch).

Apply now

Postdoctoral researcher – Brucella physiology in clinical human samples (100%)

The Biozentrum of the University of Basel is one of the leading Life Sciences Institutes in the world. It accommodates 30 research groups and 500 employees investigating how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birthplace of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

A postdoc position is available in the group of Prof. Christoph Dehio (www.biozentrum.unibas.ch/dehio)

The advertised position is part of the National Center of Competence in Research AntiResist (2020-2032; https://nccr-antiresist.ch/). NCCR AntiResist is a Swiss-wide interdisciplinary center for antibiotic research with strong collaborations between biologists, clinicians, engineers, computational scientists and chemists. Our goals are to develop relevant laboratory models mimicking Brucella infection and the response to antibiotics in human patients, and to use these models to discover innovative strategies for combating human brucellosis. At the core of this venture are direct links between basic and clinical research and bioengineering.

Your responsibilities are

To develop innovative approaches to isolate and analyze Brucella and Brucella-infected cells from human patient samples in order to better understand the pathogen-host interaction and associated cellular physiological processes on both the host and bacterial side. The gained knowledge will then be used for refining or developing new in-vitro infection models to better study Brucella-host interaction and the resilience to antibiotics.

Your profile

You obtained a PhD in immunology, cell biology, clinical microbiology, or a related field. You have a genuine interest in bacterial-host interaction and in method development. Experience in immunophenotyping and related FACS-based application as well as with analysis from large MS or RNA-seq dataset would be an asset. Willingness to work at Biosafety Level 3 for follow-up experiments would also be a great advantage.

We offer

Our multidisciplinary group includes microbiologists and cell biologist with an expertise in bacterial pathogenesis of zoonosis with chronic manifestations (a list of recent publications can be found here. We have an excellent support from various core facilities with expert staff as well as a very strong multi-disciplinary collaborative environment within the frame of the NCCR AntiResist project.

The position will start in January 2021 or upon agreement and the funding is available for at least three years.

Basel is an international city with people from 150 nations. Located on the border where three countries meet - Switzerland-Germany- France -, it is Europe’s most important life sciences hub. Basel provides a high standard of living and a rich and varied cultural atmosphere.

Application / Contact

Please apply online; only on-line applications will be reviewed. Upload the following three separate PDF documents: 1) Your CV with contacts for three references 2) Motivation letter explaining why you are a good candidate for this job offer 3) List of all your publications (including pre-prints). For up to three publications most relevant to this job offer describe shortly (up to 200 words) your role as well as why is the publication relevant (for example: what techniques you learned, what experience you gained, etc.).

Incomplete applications will be disregarded. Reviewing of applications will begin on Nov 30, 2020 and continue until the position is filled. For general inquiries please send an e-mail to recruitment@nccr-antiresist.ch.

Apply now

Postdoctoral researcher – Postdoctoral researcher – Molecular basis of Brucella type-IV-secretion effector delivery into host cells (100%

The Biozentrum of the University of Basel is one of the leading Life Sciences Institutes in the world. It accommodates 30 research groups and 500 employees investigating how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birthplace of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

A postdoc position is available in the research group of Prof. Christoph Dehio (www.biozentrum.unibas.ch/dehio).

We are interested in the molecular basis underlying pathogenicity of Brucella with a specific interest on its type IV secretion (T4S) system and associated effector proteins. Our goals are to resolve the molecular basis of Brucella T4S-dependent effector secretion by establishing new approaches to address this fundamental question.

Your responsibilities are

While the panel of published effectors translocated by Brucella has recently expended, essential aspects of the translocation process remain elusive. In this context, your goal will be to develop innovative approaches to study the molecular basis of Brucella T4S effector secretion into host cells, by combining the use of surrogate models and work under Biosafety Level 3 (BSL3) conditions. The project will include development of new genetic tools and reporters, biochemical characterization of interaction partners and establishment of new screening methods to identify new effector proteins.

Your profile

You obtained a PhD in, microbiology, synthetic biology or a related research field. You have experience with bacterial secretion system(s) and a genuine interest in bacterial-host interaction. You are creative and willing to contribute to the development of innovative research tools to uncover the molecular mechanism underlying effector translocation by Brucella T4S.

We offer

Our multidisciplinary group includes microbiologists and cell biologist with an expertise in bacterial pathogenesis of zoonosis with chronic manifestations, with a special focus on T4S systems and effectors (a list of recent publications can be found here. We have an excellent support from various core facilities with expert staff as well as a very strong multi-disciplinary collaborative environment.

The position will start in January 2021 or upon agreement and the funding will be available for at least three years.

Basel is an international city with people from 150 nations. Located on the border where three countries meet - Switzerland-Germany- France -, it is Europe’s most important life sciences hub. Basel provides a high standard of living and a rich and varied cultural atmosphere.

Application / Contact

Please apply online; only on-line applications will be reviewed. Upload at least the following three separate PDF documents: 1) your CV with contacts for three references, 2) a motivation letter explaining why you are a good candidate for this job offer and 3) a list of all your publications (including pre-prints). For up to three publications most relevant to this job offer, describe shortly (up to 200 words) your role as well as why is the publication relevant to this position.

Incomplete applications will be disregarded. Reviewing of applications will begin on Nov 30, 2020 and continue until the position is filled.. For general inquiries please send an e-mail to christoph.dehio@unibas.ch.

Apply now

Data Scientist Proteomics (100%)

Starting immediately or upon agreement

The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 30 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birthplace of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

We are looking to recruit a self-motivated Data Scientist to join our team at the Proteomics Core Facility (PCF). The PCF provides state-of-the art proteomic methodologies to support life science research at the Biozentrum. It is tightly integrated in an internationally leading scientific surrounding and contributes to multiple interdisciplinary projects. The position offers a challenging opportunity at a key intersection of rapidly moving areas of research.

Your responsibilities

The successful applicant’s main responsibilities will be the implementation and maintenance of informatics solutions to analyse and interpret quantitative mass spectrometric data which is generated by the various workflows offered by the PCF. These include global (LFQ, TMT, SWATH) and targeted (PRM) mass spectrometric analysis of proteins, modifications, protein/drug interactions and structural constraints. The position involves the development and implementation of informatics solutions to manage, display and search proteomics datasets, the database-based management of results, support in data analysis and the possibility for independent research projects.

Your profile

Applicants should have a degree in a life science or computational discipline. Excellent skills in R based programming and good understanding of Linux and Windows operation systems as well as prior experience with the analysis of quantitative biological datasets are essential. Hands-on experience with LC-MS systems and experience in the statistical analysis of proteomics data would be advantageous, but are not required. In addition, the role requires good communication and organization skills, the ability to work well in a team, as well as an advanced knowledge of written and spoken English.

We offer

The position offers a challenging opportunity to join a growing and rapidly evolving bioanalytical field and to join a team of highly motivated scientists. The position is initially for 2 years, with the possibility of further extension after positive evaluation. Salary and benefits according to University of Basel standards.

Application / Contact

The application should include a brief personal statement, explaining how your qualifications and experience make you a good candidate for this job, together with a full, up-to-date CV and addresses of 2 references.

We start reviewing applications from 30 November 2020 until the position is filled. In all cases, you will be notified of the outcome of your application. Please note that only online applications will be accepted.

For further information, please contact Dr. Alexander Schmidt, Head of Proteomics Core Facility, +41 61 207 20 59, alex.schmidt@unibas.ch
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Laboratory Technician (80-100%)

Starting January 1, 2021 or upon mutual agreement

The Biozentrum of the University of Basel is one of the leading life sciences institutes in the world. It consists of 30 groups and 500 employees that research how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birthplace of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

The Scheiffele Lab at Biozentrum is searching for a highly motivated 80-100% laboratory technician.


Your responsibilities

The successful applicant will join a dynamic research group studying the development of neuronal networks in the mammalian brain and pathophysiology of autism-spectrum disorders. Main responsibilities include behavioral and surgical procedures in mice, molecular biology and biochemical experiments. Approximately 50% of the work will be broadly supporting functions and maintenance of the lab and 50% will be directly linked to a specific project in the laboratory.


Your profile

Applicants should have a degree as “Laborant/in” or a Bachelor Degree in Biology or related topics. Previous experience in mouse husbandry, surgery, and molecular biology applications is desired. The role requires flexibility, excellent organizational and communication skills, and the ability to multi-task. Enthusiasm and motivation for biological research are critical. The primary language of the laboratory and the Biozentrum is English.


We offer

This position offers an exciting opportunity for a highly motivated individual to contribute to a vibrant international research community and to tackle a challenging question in neuroscience research. The work is part of the European AIMS-2-TRIALS Network which explores the biology of autism to tailor treatments and develop new medicines.

The position is available from Jan 1, 2021. The initial contract will be for one year with the possibility of longer-term extension.

For more information on research in the Scheiffele Lab see: http://www.biozentrum.unibas.ch/scheiffele


Application / Contact

The application should include a brief personal statement, explaining how your qualifications and experience relate to the role, together with a full, up-to-date CV and addresses of 2 references. Please note that only online applications will be accepted.

We start reviewing applications from December 1, 2020 until the position is filled. In all cases, you will be notified of the outcome of your application.

For any informal enquiries, please contact: dietmar.schreiner@unibas.ch

Apply now

Research Data Manager (80-100%) – NCCR AntiResist

Starting per agreement as soon as possible

The Biozentrum of the University of Basel is one of the leading Life Sciences Institutes in the world. It accommodates 30 research groups and 500 employees investigating how molecules and cells create life, spanning the scale from atom to organism. Founded in 1971, the Biozentrum has been the birthplace of many fundamental discoveries in biology and medicine, spawning several Nobel Laureates.

National Center of Competence in Research (NCCR) “AntiResist: New approaches to combat antibiotic-resistant bacteria” (2020-2032) is a Swiss-wide interdisciplinary center for antibiotic research with strong collaborations between biologists, clinicians, engineers, computational scientists and chemists. This network is funded by the Swiss National Science Foundation as part of their major support in strengthening research in areas of strategic importance. Our goals are to develop laboratory models mimicking infection processes in human patients, and to use these models to discover innovative antibiotics and alternative strategies to combat antibiotic-resistant bacteria. At the core of this venture are direct links between basic and clinical research, bioengineering, and pharmaceutical industry to help solving the current antibiotic crisis.

NCCR AntiResist is recruiting for the position of Research Data Manager.


The position

The Research Data Manager is responsible for building and managing the Research Data Ecosystem of the consortium. The Research Data Ecosystem of the project will consist of a heterogeneous set of existing, and possibly some new data management systems for different types of data (microscopy, next-generation sequencing, proteomics). In collaboration with data providers involved in the project (e.g. technology platforms) and with scientific IT platforms at the University Hospital Basel (USB) and University of Basel, our new collaborator will develop and maintain an environment enabling data federation (e.g. cross-linking identifiers at the various service platforms and/or linking data hosted in local data management systems).

Key responsibilities include, but are not limited to the following:

  • Maintain a catalog of data sources, data types and an overview of the data flows in the project.
  • Contribute to design and implementation of the code necessary to ensure smooth interoperability between data management systems and the federation environment (database “crawlers”, monitoring availability of data in federated systems, etc.)
  • In collaboration with institutional Technology Platform, set-up and maintain the database infrastructure to host and inter-link research data (data federation)
  • Ensure integrity of the research data and monitor compliance with documentation guidelines by AntiResist scientists.
  • Develop crawlers tailored to different subject specific databases that stores data and to backlink
  • Assist with data annotation and metadata creation
In execution of these functions, the Research Data Manager is at the center of the data produced by the entire consortium. Making sure that data produced by the consortium are managed along the FAIR principles (findable, accessible, interoperable, reusable) is paramount to the success of the project.

Who You Are

For this challenging and exciting position, we are looking for these qualifications:

  • MSc or PhD in Computer Science with experience in life sciences, Computational sciences or equivalent.
  • Proficient in managing life-science data over the entire data life cycle: from data capture, annotation with controlled vocabularies/ontologies, QC and curation, to publication in domain-specific repositories (e.g. Pride, EGA, PDB, etc.)
  • Min. 3 years of experience working in a support role with more than one research data management system (e.g. LIMS (e.g. Labkey), ELN, data type-specific data management system (Omero, Orthanc, etc.)
  • Highly proficient with at least one scripting language (Python preferred), including development of interface code between systems using APIs (XML, JSON)
  • In-depth understanding of database technologies (SQL, NoSQL; schema design, APIs)
  • Thrives on multidisciplinary team collaborations
  • Excellent organizational skills, capable of working autonomously
  • Working language is English (oral and written)

We offer

We offer a highly visible, vibrant, inclusive, and flexible international working environment in a network of world-leading research institutes and pharmaceutical companies in Switzerland. The working place is at University of Basel as home institution of the NCCR. The new collaborator will report to the scientific leadership of the NCCR project and will be embedded in sciCORE, the scientific computing center of University of Basel (https://scicore.unibas.ch/). Salary will be commensurate with institutional guidelines of the University of Basel and level of experience. The position is available immediately. The initial contract is for 1 year, with the expectation to extend to each continued 4-year phase of the NCCR. The position of Research Data Manager is extendable up to the full 12-year program.


Application / Contact

The application should include a brief personal statement, explaining how your qualifications and experience make you a good candidate for this job, together with a full, up-to-date CV and addresses of 2 references.

We start reviewing applications from 2 November 2020 until the position is filled. Please note that only online applications will be accepted. For further information, please contact Dr. Anne-Cécile Hiebel (AntiResist Coordinator) or Prof. Christoph Dehio (AntiResist Director) at recruitment@nccr-antiresist.ch.

Apply now